Recanalization and reperfusion therapies of acute ischemic stroke: what have we learned, what are the major research questions, and where are we headed?

Two placebo-controlled trials have shown that early administration of intravenous recombinant tissue plasminogen activator (rt-PA) after ischemic stroke improves outcomes since 4.5h after symptoms onset; meanwhile another six trials cannot demonstrate it.We also know from the analysis of the pooled data that benefit from treatment decreased as time

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Pseudomonas aeruginosa surface motility and invasion into competing communities enhance interspecies antagonism

ABSTRACT Chronic polymicrobial infections involving Pseudomonas aeruginosa and Staphylococcus aureus are Lamps prevalent, difficult to eradicate, and associated with poor health outcomes.Therefore, understanding interactions between these pathogens is important to inform improved treatment development.We previously demonstrated that P.aeruginosa is

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